47 patients with unexplained (n=35) or alloimmunologic(n=12) recurrent abortion were studied for the evaluation of the clinical results after lymphocyte immunization.
@ES The results were as follows;
@EN 1. The mean age of these patients was 32.1 years old and the mean number of spontaneous abortion was 3.5.
2. Among 47 immunized women 31 became pregnant, 27 had successful pregnancies, and four had repeated abortions.
3. Thus, the success rate after lymphocyte immunization was 87%(27/31).
4. The mean interval from immunization of pregnancy was 6.7 weeks, 16 became pregnant before eight weeks, eight had after eight weeks, and seven were immunized in early pregnancy.
5. The outcomes of immunotherapy in 21 delivered women were such that the mean gestational weeks was 39.4 and the mean birth weight of neonates was 3,315 gm. The fetal complications of immunotherapy in this study were one preterm delivery
(4.8%),
and
two intrauterine growth retardation(9.5%).
In conclusion, our study shows that immunization with paternal cells remains a safe and effective treatment for the majority of women with unexplained or alloimmunologic recurrent spontaneous abortion, resulting in developmentally normal babies
with
normal birth weight.
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